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1

DNA Vaccines: Immunology, Application, and Optimization*

Gurunathan, Sanjay, Klinman, Dennis M., Seder, Robert A.

Journal:

Annual Review of Immunology

Year:

2000

Language:

english

File:

PDF, 350 KB

english, 2000

2

CpG DNA as a vaccine adjuvant

Bode, Christian, Zhao, Gan, Steinhagen, Folkert, Kinjo, Takeshi, Klinman, Dennis M

Journal:

Expert Review of Vaccines

Year:

2011

Language:

english

File:

PDF, 846 KB

english, 2011

3

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

Scheiermann, Julia, Klinman, Dennis M.

Journal:

Year:

2014

Language:

english

File:

PDF, 517 KB

english, 2014

4

DNA vaccines: safety and efficacy issues

Dennis M. Klinman, Mitsuhiro Takeno, Motohide Ichino, Mili Gu, Galina Yamshchikov, Gil Mor, Jacqueline Conover

Journal:

Seminars in Immunopathology

Year:

1997

Language:

english

File:

PDF, 769 KB

english, 1997

5

CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases

Dennis M. Klinman, Sven Klaschik, Takashi Sato, Debbie Tross

Journal:

Advanced Drug Delivery Reviews

Year:

2009

Language:

english

File:

PDF, 269 KB

english, 2009

6

Immunostimulatory CpG oligonucleotides: Effect on gene expression and utility as vaccine adjuvants

Dennis M. Klinman, Sven Klaschik, Koji Tomaru, Hidekazu Shirota, Debra Tross, Hidekazu Ikeuchi

Journal:

Year:

2010

Language:

english

File:

PDF, 810 KB

english, 2010

7

Large intestine–targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection

Zhu, Qing, Talton, James, Zhang, Guofeng, Cunningham, Tshaka, Wang, Zijian, Waters, Robert C, Kirk, James, Eppler, Bärbel, Klinman, Dennis M, Sui, Yongjun, Gagnon, Susan, Belyakov, Igor M, Mumper, Rus

Journal:

Nature Medicine

Year:

2012

Language:

english

File:

PDF, 653 KB

english, 2012

8

Recent progress concerning CpG DNA and its use as a vaccine adjuvant

Shirota, Hidekazu, Klinman, Dennis M

Journal:

Expert Review of Vaccines

Year:

2014

Language:

english

File:

PDF, 409 KB

english, 2014

9

CpG DNA as a vaccine adjuvant

Klinman, Dennis M

Journal:

Expert Review of Vaccines

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

10

Positive and negative regulatory elements contribute to CpG oligonucleotide-mediated regulation of human IL-6 gene expression

Fumihiko Takeshita, Ken J. Ishii, Atsuhisa Ueda, Yoshiaki Ishigatsubo, Dennis M. Klinman

Journal:

European Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 191 KB

english, 2000

11

CpG ODN-mediated regulation of IL-12 p40 transcription

Fumihiko Takeshita, Dennis M. Klinman

Journal:

European Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 197 KB

english, 2000

12

CpG motifs of DNA vaccines induce the expression of chemokines and MHC class II molecules on myocytes

Alexandru C. Stan, Sofia Casares, Teodor-Doru Brumeanu, Dennis M. Klinman, Constantin A. Bona

Journal:

European Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 475 KB

english, 2001

13

CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells

Mayda Gursel, Daniela Verthelyi, Dennis M. Klinman

Journal:

European Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 196 KB

english, 2002

14

Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides

Rainald A. Zeuner, Ken J. Ishii, Martin J. Lizak, Ihsan Gursel, Hiroshi Yamada, Dennis M. Klinman, Daniela Verthelyi

Journal:

Arthritis & Rheumatism

Year:

2002

Language:

english

File:

PDF, 1.25 MB

english, 2002

15

Does activation of the innate immune system contribute to the development of rheumatoid arthritis?

Journal:

Arthritis & Rheumatism

Year:

2003

Language:

english

File:

PDF, 47 KB

english, 2003

16

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis

Rainald A. Zeuner, Daniela Verthelyi, Mayda Gursel, Ken J. Ishii, Dennis M. Klinman

Journal:

Arthritis & Rheumatism

Year:

2003

Language:

english

File:

PDF, 91 KB

english, 2003

17

Idiotypy and autoimmunity

Dennis Marc Klinman, Alfred David Steinberg

Journal:

Arthritis & Rheumatism

Year:

1986

Language:

english

File:

PDF, 891 KB

english, 1986

18

Quantitation of IgM- and IgG-secreting B cells in the peripheral blood of patients with systemic lupus erythematosus

Dennis M. Klinman, Akira Shirai, Yoshiaki Ishigatsubo, Jacqueline Conover, Alfred D. Steinberg

Journal:

Arthritis & Rheumatism

Year:

1991

Language:

english

File:

PDF, 595 KB

english, 1991

19

Vh family utilization by igg anti-dna–secreting lymphocytes derived from autoimmune mrl-lpr/lpr mice

Dennis M. Klinman, Dale K. Dellacqua, Jacqueline Conover, Konrad Huppi

Journal:

Arthritis & Rheumatism

Year:

1993

Language:

english

File:

PDF, 813 KB

english, 1993

20

Cross-reactivity of igm- and igg-secreting b cells in autoimmune mice

Yoshiaki Ishigatsubo, Toshihisa Igarashi, Shigeru Ohno, Atsuhisa Ueda, Takao Okubo, Dennis M. Klinman

Journal:

Arthritis & Rheumatism

Year:

1993

Language:

english

File:

PDF, 428 KB

english, 1993

21

Reply: Are IgG anti-DNA Secreting Hybridomas Representative?

Dennis M. Klinman

Journal:

Arthritis & Rheumatism

Year:

1994

Language:

english

File:

PDF, 266 KB

english, 1994

22

Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10: Interferon-γ–secreting cells in the peripheral blood

Eri Hagiwara, Mark F. Gourley, Susie Lee, Dennis M. Klinman

Journal:

Arthritis & Rheumatism

Year:

1996

Language:

english

File:

PDF, 597 KB

english, 1996

23

Suppressive oligonucleotides protect against collagen-induced arthritis in mice

Li Dong, Shu-ichi Ito, Ken J. Ishii, Dennis M. Klinman

Journal:

Arthritis & Rheumatism

Year:

2004

Language:

english

File:

PDF, 91 KB

english, 2004

24

Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice

Li Dong, Shuichi Ito, Ken J. Ishii, Dennis M. Klinman

Journal:

Arthritis & Rheumatism

Year:

2005

Language:

english

File:

PDF, 176 KB

english, 2005

25

Effect of anti-Ia treatment on the production of anti-DNA antibody by NZB mice

Dennis M. Klinman, Michael D. Lefkowitz, Elizabeth S. Raveche, Alfred D. Steinberg

Journal:

European Journal of Immunology

Year:

1986

Language:

english

File:

PDF, 674 KB

english, 1986

26

Autoantibody production is associated with polyclonal B cell activation in autoimmune mice which express the lpr or gld genes

Yoshiaki Ishigatsubo, Alfred D. Steinberg, Dennis M. Klinman

Journal:

European Journal of Immunology

Year:

1988

Language:

english

File:

PDF, 541 KB

english, 1988

27

B-1a and conventional B cells from autoimmune NZB. H-2bm12 mice exhibit similar functional characteristics in vivo

Dennis M. Klinman, Kevin L. Holmes, Jacqueline Conover, Bor-Luen Chiang, M. Eric Gershwin

Journal:

European Journal of Immunology

Year:

1993

Language:

english

File:

PDF, 690 KB

english, 1993

28

Cross-reactivity of IgG anti-DNA-secreting B cells in patients with systemic lupus erythematosus

Dennis M. Klinman, Akira Shirai, Jacqueline Conover, Alfred D. Steinberg

Journal:

European Journal of Immunology

Year:

1994

Language:

english

File:

PDF, 616 KB

english, 1994

29

CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection

Ken J. Ishii, Shuichi Ito, Tomohiko Tamura, Hiroaki Hemmi, Jacqueline Conover, Keiko Ozato, Shizuo Akira, Dennis M. Klinman

Journal:

European Journal of Immunology

Year:

2005

Language:

english

File:

PDF, 327 KB

english, 2005

30

TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF

Fumihiko Takeshita, Ken J. Ishii, Kouji Kobiyama, Yoshitsugu Kojima, Cevayir Coban, Shin Sasaki, Norihisa Ishii, Dennis M. Klinman, Kenji Okuda, Shizuo Akira, Koichi Suzuki

Journal:

European Journal of Immunology

Year:

2005

Language:

english

File:

PDF, 286 KB

english, 2005

31

Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5

Shinya Abe, Kenji Okuda, Takehiro Ura, Asami Kondo, Atsushi Yoshida, Shinji Yoshizaki, Hiroyuki Mizuguchi, Dennis Klinman, Masaru Shimada

Journal:

The Journal of Gene Medicine

Year:

2009

Language:

english

File:

PDF, 329 KB

english, 2009

32

A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV

Ke-Qin Xin, Takaaki Ooki, Nao Jounai, Hiroaki Mizukami, Kenji Hamajima, Yoshitsugu Kojima, Kenji Ohba, Yoshihiko Toda, Syu-Ichi Hirai, Dennis M. Klinman, Keiya Ozawa, Dr Kenji Okuda

Journal:

The Journal of Gene Medicine

Year:

2003

Language:

english

File:

PDF, 150 KB

english, 2003

33

Contribution of the rev gene to the immunogenicity of DNA vaccines targeting the envelope glycoprotein of HIV

Nao Jounai, Kenji Okuda, Yoshitsugu Kojima, Yoshihiko Toda, Kenji Hamajima, Kenji Ohba, Dennis Klinman, Dr Ke-Qin Xin

Journal:

The Journal of Gene Medicine

Year:

2003

Language:

english

File:

PDF, 228 KB

english, 2003

34

The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides

Masaki Yamamoto, Takashi Sato, Joel Beren, Daniela Verthelyi, Dennis M. Klinman

Journal:

Year:

2011

Language:

english

File:

PDF, 382 KB

english, 2011

35

Systemic but not mucosal immunity induced by AVA prevents inhalational anthrax

Dennis M. Klinman, Debra Currie, Gloria Lee, Vanessa Grippe, Tod Merkel

Journal:

Microbes and Infection

Year:

2007

Language:

english

File:

PDF, 387 KB

english, 2007

36

B cell activation in patients with rheumatic disease: association with an increased ratio of Th2: Th1 cytokine secreting cells

Eri Hagiwara, Yoshiaki Ishigatsubo, Dennis M. Klinman

Journal:

Modern Rheumatology

Year:

1997

Language:

english

File:

PDF, 510 KB

english, 1997

37

CpG-conjugated apoptotic tumor cells elicit potent tumor-specific immunity

Hidekazu Shirota, Dennis M. Klinman

Journal:

Cancer Immunology, Immunotherapy

Year:

2011

Language:

english

File:

PDF, 582 KB

english, 2011

38

Activation of the innate immune system by CpG oligodeoxynucleotides: immunoprotective activity and safety

Dennis M. Klinman, Soren Kamstrup, Daniela Verthelyi, Ihsan Gursel, Ken J. Ishii, Fumihiko Takeshita, Mayda Gursel

Journal:

Seminars in Immunopathology

Year:

2000

Language:

english

File:

PDF, 694 KB

english, 2000

39

Preserving primary cDNA libraries

Dennis M. Klinman, David I. Cohen

Journal:

Analytical Biochemistry

Year:

1987

Language:

english

File:

PDF, 359 KB

english, 1987

40

The regulation of DNA vaccines

Herbert A Smith, Dennis M Klinman

Journal:

Current Opinion in Biotechnology

Year:

2001

Language:

english

File:

PDF, 52 KB

english, 2001

41

CpG DNA: recognition by and activation of monocytes

Dennis M. Klinman, Fumihiko Takeshita, Ihsan Gursel, Cynthia Leifer, Ken J. Ishii, Daniela Verthelyi, Mayda Gursel

Journal:

Microbes and Infection

Year:

2002

Language:

english

File:

PDF, 161 KB

english, 2002

42

Use of CpG oligodeoxynucleotides as immune adjuvants

Dennis M. Klinman, Debra Currie, Ihsan Gursel, Daniela Verthelyi

Journal:

Immunological Reviews

Year:

2004

Language:

english

File:

PDF, 183 KB

english, 2004

43

Contribution of interferon-β to the immune activation induced by double-stranded DNA

Hidekazu Shirota, Ken J. Ishii, Hiroki Takakuwa, Dennis M. Klinman

Journal:

Year:

2006

Language:

english

File:

PDF, 317 KB

english, 2006

44

Accelerated wound healing mediated by activation of Toll-like receptor 9

Takashi Sato, Masaki Yamamoto, Takeshi Shimosato, Dennis M. Klinman

Journal:

Wound Repair and Regeneration

Year:

2010

Language:

english

File:

PDF, 1.54 MB

english, 2010

45

Theoretical and Experimental Approaches to Generalized Autoimmunity

Alfred D. Steinberg, Arthur M. Krieg, Mark F. Gourley, Dennis M. Klinman

Journal:

Immunological Reviews

Year:

1990

Language:

english

File:

PDF, 11.21 MB

english, 1990

46

Therapeutic Applications and Mechanisms Underlying the Activity of Immunosuppressive Oligonucleotides

Dennis M. Klinman, Debbie Tross, Sven Klaschik, Hidekazu Shirota, Takeshi Sato

Journal:

Annals of the New York Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 119 KB

english, 2009

47

CpG motifs in bacterial DNA trigger direct B-cell activation

Krieg, Arthur M., Yi, Ae-Kyung, Matson, Sara, Waldschmidt, Thomas J., Bishop, Gail A., Teasdale, Rebecca, Koretzky, Gary A., Klinman, Dennis M.

Journal:

Year:

1995

File:

PDF, 431 KB

1995

48

10.1038/74715

Krause, Philip R., Klinman, Dennis M.

Journal:

Nature Medicine

Year:

2000

Language:

english

File:

PDF, 115 KB

english, 2000

49

10.1038/82072

Krause, Philip R., Klinman, Dennis M.

Journal:

Nature Medicine

Year:

2000

Language:

english

File:

PDF, 64 KB

english, 2000

50

Toward clinical trials of DNA vaccines against malaria

Hoffman, Stephen L, Doolan, Denise L, Sedegah, Martha, Wang, Ruobing, Scheller, Libia F, Kumar, Anita, Weiss, Walter R, Le, Thong P, Klinman, Dennis M, Hobart, Peter

Journal:

Immunology & Cell Biology

Year:

1997

Language:

english

File:

PDF, 3.87 MB

english, 1997